Consideration of a liquid mutation accumulation experiment to measure mutation rates by successive serial dilution.
S. Baehr, W.-C. Ho, S. Perez, A. Cenzano, K. Hancock, L. Patrick, A. Brown, S. MIller, M. Lynch
The paper proposes a liquid-phase mutation-accumulation experiment to measure mutation rates and spectra, demonstrating it can replicate results from plate-based experiments and detect a modified mutation spectrum.
bioRxiv · Aug 31, 2023Microbiology