S. Miller

A dominant role of TGFβ in regulating T-cell size and physiology

This study shows TGFβ profoundly regulates T-cell size and physiology by modulating gene expression and transcription factor networks, independent of other cytokines.

Extracellular Matrix-Induced Genes May Reduce Response to Rapamycin in LAM

This study identifies extracellular matrix genes that reduce rapamycin response in LAM cells and suggests repurposed inhibitors as potential therapies.

mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis

This study shows mTOR dysregulation in LAM causes IL6 production and senescence in AT2 cells, impairing lung repair, and suggests targeting IL6 may help.

Employing a honeybee olfactory neural circuit as a novel gas sensor for the detection of human lung cancer biomarkers

This paper uses honeybee olfactory circuits to detect human lung cancer biomarkers in breath, achieving high classification accuracy for both individual markers and complex mixtures.

Consideration of a liquid mutation accumulation experiment to measure mutation rates by successive serial dilution.

The paper proposes a liquid-phase mutation-accumulation experiment to measure mutation rates and spectra, demonstrating it can replicate results from plate-based experiments and detect a modified mutation spectrum.

A genome-wide cytotoxicity screen of Cluster F1 mycobacteriophage Girr reveals novel inhibitors of Mycobacterium smegmatis growth

This study screens phage genes to identify inhibitors of Mycobacterium smegmatis growth, finding 29 toxic genes, 12 of which are novel antimicrobial proteins.

Tiny Earth CURE improves student persistence in science

This study shows that the Tiny Earth CURE improves scientific self-efficacy, identity, and persistence intentions among students, particularly those from historically excluded communities.

Fine-scale variability in coral bleaching and mortality during a marine heatwave

This study tracks coral bleaching and mortality during a marine heatwave, finding that spatial and taxonomic differences in bleaching are driven by environmental factors, habitat complexity, and species composition.

Genetic compensation of triacylglycerol biosynthesis in the green microalga Chlamydomonas reinhardtii

This study shows genetic compensation in Chlamydomonas reinhardtii for triacylglycerol biosynthesis genes under stress, with PDAT compensating DGTT1 knockout and maintaining lipid homeostasis.

An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces sterile immunity and prevents transmission of SARS-CoV-2 between cats

This paper develops a replicon-based vaccine that prevents SARS-CoV-2 infection and transmission in cats.

Bacterial adaptation by a transposition burst of an invading IS element

This study shows that a single transposable element drives adaptation in cyanobacteria over 400 generations through copy-and-paste activity.

Lysyl oxidase-like 2 (LOXL2) is Increased in Asthma and Contributes to Asthmatic Airway Remodelling

This study shows LOXL2 is increased in asthma and contributes to airway remodelling by enhancing TGFβ activation and ECM stiffness.

Structure and lipid dynamics in the A. baumannii maintenance of lipid asymmetry (MLA) inner membrane complex

This study reports cryo-EM structures of the A. baumannii MLA complex in different states and proposes a molecular mechanism for lipid transport.

Investigating Transfusion-Related Sepsis using Culture-Independent Metagenomic Sequencing

This study uses metagenomic sequencing to identify pathogens in transfusion-related sepsis cases, revealing a novel Acinetobacter species and demonstrating the utility of culture-independent methods.

Antibody Targeting of B7-H4 Enhances the Immune Response in Urothelial Carcinoma

This study identifies B7-H4 as a potential therapeutic target in bladder cancer, showing that anti-B7-H4 antibodies enhance immune responses and reduce tumor size in preclinical models.

Rapid, ultra-local adaptation facilitated by phenotypic plasticity

The paper shows that phenotypic plasticity and genetic accommodation drive rapid adaptive divergence in burying beetles despite gene flow between populations.

Hypomethylation of STAT1 and HLA-DRB1 is associated with type-I interferon-dependent HLA-DRB1 expression in lupus CD8+ T cells

This study identifies hypomethylation of STAT1 and HLA-DRB1 in lupus CD8+ T cells, linking it to type-I interferon-dependent HLA-DRB1 expression and immune activation.

MYCN Amplification and ATRX Mutations are Incompatible in Neuroblastoma

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children

This study develops a metagenomic sequencing assay to detect missed pathogens in immunocompromised children, finding increased sensitivity for identifying potential pathogens in lung samples.

Novel bacterial lineages associated with boreal moss species

The paper identifies novel bacterial lineages in boreal mosses, showing host identity strongly influences community composition and revealing metabolic capabilities of understudied taxa.