Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with loss of proteostasis
J. Paxman, Z. Zhou, R. O'Laughlin, Y. Li, W. Tian, H. Su, Y. Jiang, S. E. Holness, E. Stasiowski, L. Tsimring, L. Pillus, J. Hasty, N. Hao
The paper shows that reduced rDNA stability in yeast leads to rRNA-binding protein aggregation, linking chromatin instability to proteostasis loss during aging.
bioRxiv · Dec 6, 2021 · PreprintCell Biology