H. Su

Single-cell resolved differentiation of pre-Kranz anatomy in maize leaf primordia

The paper uses single-nucleus RNA sequencing to study cell heterogeneity and developmental trajectories in maize leaf primordia, identifying potential regulators of Kranz anatomy development.

Cas12a/3 crRNAs RNP transformation enables transgene-free multiplex genome editing, long deletions, and inversions in citrus chromosome in the T0 generation

Proteome of human glioblastoma and meningioma tissue small extracellular vesicles

This study isolates and characterizes small extracellular vesicles directly from human brain tumor tissue, identifying novel proteins and pathways associated with these vesicles.

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

Multi-omics characterization of highly enriched human plasma extracellular vesicles.

This study isolates and characterizes small extracellular vesicles from human plasma using multi-omics approaches, revealing novel protein and lipid profiles with potential biomarker value.

DR5 disulfide bonding as a sensor and effector of protein folding stress

This study shows that disrupting DR5 disulfide bonds activates pro-apoptotic signaling and reveals DR5 disulfide bonding as a sensor and effector of ER stress in cancer cells.

The Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy

This study identifies RBX2 as a key component of the CRL5 ubiquitin ligase that regulates mitophagy in cardiomyocytes independently of PARKIN, maintaining cardiac homeostasis.

A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.

AP-1 regulates heterogeneous cellular dormancy in TNBC

The paper identifies heterogeneous subpopulations of slow-cycling cells in TNBC and shows AP-1, particularly the JunB subunit, regulates dormancy and drug resistance.

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

The paper investigates an activating PIK3R1 variant linked to immunodeficiency and finds it acts as a dominant negative, reducing p110 signaling and explaining overlapping phenotypes.

High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by systematic metabolic engineering

This study engineered Yarrowia lipolytica to overproduce nervonic acid through metabolic pathway modifications, achieving high titers and purity.

Efficient generation of transgene-free canker-resistant Citrus sinensis using Cas12a/crRNA ribonucleoprotein

This study generates transgene-free canker-resistant citrus plants using Cas12a/crRNA RNP editing, achieving high mutation rates and regulatory approval.

Flow-induced mechanical coupling between perinuclear actin cap and nucleus governs spatiotemporal regulation of YAP transport

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

Single-cell Landscape Analysis Unravels Molecular Programming of the Human B Cell Compartment in Chronic GVHD

This study uses scRNA-Seq to analyze B cells from allo-HCT patients, revealing molecular differences in B cell subsets associated with active versus non-active cGVHD.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

Dynamic Expedition of Leading Mutations in SARS-CoV-2 Spike Glycoproteins

The paper introduces a time-resolved statistical method to analyze the evolutionary dynamics of SARS-CoV-2 spike mutations and quantifies mutation strength using the L-index.

Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with loss of proteostasis

The paper shows that reduced rDNA stability in yeast leads to rRNA-binding protein aggregation, linking chromatin instability to proteostasis loss during aging.

The gut microbial signature of gestational diabetes mellitus and the association with diet intervention

This study examines gut microbiota composition in GDM patients before and after diet intervention, finding that diet affects the Firmicutes/Bacteroidetes ratio and specific taxa rather than altering the overall microbial pattern.

The cause of on-target point mutations generated by CRISPR-Cas9 treatment in the yeast Xanthophyllomyces dendrorhous

This study identifies on-target point mutations caused by CRISPR-Cas9 in yeast, showing sequence dependence and involvement of NHEJ components.

An ultrapotent neutralizing bispecific antibody with broad spectrum against SARS-CoV-2 variants

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

BSCL2/Seipin Deficiency in Heart Causes Energy Deficit and Heart Failure via Inducing Excessive Lipid Catabolism

This study shows that BSCL2 deficiency in the heart causes heart failure through excessive lipid catabolism, reduced energy reserves, and ATP levels, which can be mitigated by inhibiting fatty acid oxidation or high-fat diet.

Structural basis for HCMV Pentamer recognition by antibodies and neuropilin 2

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence

This study identifies GIMAP5 as a lymphocyte-specific regulator of senescence, showing that rapamycin can restore naive T cell levels in GIMAP5-deficient patients.

Genetic models of latent tuberculosis in mice reveal differential control by adaptive immunity

This study develops genetic mouse models of latent tuberculosis, revealing that adaptive immunity differentially controls relapse depending on the model used.

CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

Shoot-derived miR2111 controls legume root and nodule development

This study identifies miR2111 as a shoot-derived signal that regulates legume root nodule development and root system architecture by targeting TML.