Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis
M. Vedantham, L. Polari, A. Poosakkannu, R. G. Pinto, M. Sakari, J. Laine, P. Sipila, J. Maatta, H. Gerke, T. M. Rissanen, P. Rantakari, D. M. Toivola, A. T. Pulliainen
This study shows that Parp14 deficiency in mice worsens colitis by impairing epithelial barrier integrity and altering inflammation-related gene expression.
bioRxiv · Jan 12, 2024Immunology