Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel
A. Sumino, Y. Zhao, D. Mukai, T. Sumikama, L. Puppulin, M. Hattori, M. Shibata
This study uses HS-AFM to visualize TRPV1 structural fluctuations, showing agonist RTX increases fluctuations while antagonist CPZ decreases them, affecting channel gating.
bioRxiv · Jan 22, 2023Physiology