Functional metagenomics reveals an alternative, broad-specificity pathway for metabolism of carbohydrates in human gut commensal bacteria
S. A. Nasseri, A. C. Lazarski, I. L. Lemmer, C. Y. Zhang, E. Brencher, H.-M. Chen, L. Sim, L. Betschart, L. J. Worral, N. C. J. Strynadka, S. G. Withers
The paper identifies a novel, broad-specificity glycosidase pathway in gut bacteria that operates via a non-Koshland mechanism, capable of hydrolyzing diverse substrates including thioglycosides and pharmaceuticals.
bioRxiv · Mar 25, 2024Biochemistry