D. M. Francis

This study shows tomato consumption changes mouse liver gene expression and metabolite profiles, particularly affecting xenobiotic metabolism and steroidal alkaloid accumulation.

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

This study shows that short-term tomato consumption in piglets increases the ratio of Bacteroidota to Bacillota and alpha-diversity, suggesting a beneficial shift in the gut microbiome.

This study identifies novel alleles at the Anthocyanin fruit and atroviolacium loci in Solanum galapagense LA1141 that confer purple fruit pigmentation, supporting a hybridization origin and independent gain of anthocyanin production in the red-fruited tomato clade.

This study develops an mRNA-LNP vaccine (STI-7264) and a lymphatic delivery device (MuVaxx) that enhance immune responses against SARS-CoV-2 with reduced dosing.

The paper quantifies steroidal alkaloid diversity and identifies QTLs in tomato populations, finding coordinated biosynthesis and species-dependent correlations.