Author

H.-M. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. C. Lazarski· 1 shared C. Hunter· 1 shared C. Y. Zhang· 1 shared C.-C. Chen· 1 shared C.-F. Ho· 1 shared C.-H. Chen· 1 shared C.-J. Yu· 1 shared D. A. Carlson· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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1 shared paperBiochemistry

A. C. Lazarski

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Author profile →

5 papers

Recent·Most cited

Functional metagenomics reveals an alternative, broad-specificity pathway for metabolism of carbohydrates in human gut commensal bacteria

S. A. Nasseri, A. C. Lazarski, I. L. Lemmer, C. Y. Zhang, E. Brencher, H.-M. Chen, L. Sim, L. Betschart, L. J. Worral, N. C. J. Strynadka, S. G. Withers

The paper identifies a novel, broad-specificity glycosidase pathway in gut bacteria that operates via a non-Koshland mechanism, capable of hydrolyzing diverse substrates including thioglycosides and pharmaceuticals.

bioRxiv · Mar 25, 2024Biochemistry

Attenuation of polysialic acid biosynthesis in cells by the small molecule inhibitor 8-keto-sialic acid

C. Hunter, Z. Gao, H.-M. Chen, N. Thompson, W. Wakarchuk, m. nitz, S. Withers, L. M. Willis

The paper describes 8-keto-sialic acid as a non-toxic inhibitor that blocks polysialic acid synthesis by terminating chain elongation in cancer and immune cells.

bioRxiv · Sep 2, 2022Biochemistry

Death-associated protein kinase 3 (DAPK3) contributes to intestinal epithelial wound healing and the resolution of experimental colitis in mice

H.-M. Chen, D. A. Carlson, T. A. Haystead, J. A. MacDonald

This study shows that DAPK3 inhibition impairs intestinal epithelial wound healing and colitis resolution in mice by affecting YAP signaling.

bioRxiv · Dec 3, 2021 · PreprintPharmacology & Toxicology

Modulation of adenine phosphoribosyltransferase-mediated salvage to promote diabetic wound healing

G.-H. Young, J.-T. Lin, Y.-F. Cheng, C.-F. Ho, Q.-Y. Kuok, R.-C. Hsu, W.-R. Liao, C.-C. Chen, H.-M. Chen

This study shows that adenine supplementation enhances ATP levels and accelerates wound healing in diabetic mice by modulating APRT-mediated purine salvage.

bioRxiv · Apr 8, 2020 · PreprintPathology

Glucose intake hampers PKA-regulated HSP90 chaperone activity

Y.-C. Chen, P.-H. Jiang, H.-M. Chen, C.-H. Chen, Y.-T. Wang, Y.-J. Chen, C.-J. Yu, S.-C. Teng

The paper identifies Ids2 as a regulator of HSP90 chaperone activity, showing that glucose intake inhibits its function, linking nutrient sensing to proteostasis and longevity.

bioRxiv · Jul 24, 2018Cell Biology