Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naive human B cells
J. H. Lee, L. Toy, J. T. Kos, Y. Safonova, W. R. Schief, C. T. Watson, C. Havenar-Daughton, S. Crotty
The paper screens naive B cells for VRC01-class broadly neutralizing antibody precursors using a germline-targeting immunogen and single-cell BCR sequencing, finding common germline variation affecting gene usage.
bioRxiv · Mar 1, 2021Immunology