Author

L. Varela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Paleontology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. C. Hendry· 2 shared D. Cantoni· 2 shared J. L. Ortega-Roldan· 2 shared A. Kristant· 1 shared C. van de Lest· 1 shared D. K. Merriman· 1 shared E. Lozano-Andres· 1 shared E. Medina-Carmona· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

A. C. Hendry

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Femora Nutrient Foramina and Aerobic Capacity in Giant Extinct Xenarthrans

L. Varela, P. S. Tambusso, R. A. Farina

This study examines the relationship between nutrient foramen size and aerobic capacity in xenarthran mammals, finding that giant extinct species had high metabolic rates comparable to placental mammals.

bioRxiv · Sep 27, 2023Paleontology

Acute joint inflammation induces a sharp increase in the number of synovial fluid EVs and modifies their phospholipid profile

L. Varela, C. van de Lest, J. Boere, S. Libregts, E. Lozano-Andres, R. van Weeren, M. Wauben

This study examines how acute joint inflammation affects synovial fluid EVs, showing increased numbers and altered phospholipid profiles.

bioRxiv · May 5, 2023Cell Biology

Hypothalamic hormone deficiency enables physiological anorexia

S. M. Mohr, R. D. Pra, M. P. Platt, V. V. Feketa, M. Shanabrough, L. Varela, A. Kristant, H. Cao, D. K. Merriman, T. L. Horvath, S. N. Bagriantsev, E. O. Gracheva

This study shows that thyroid hormone deficiency causes anorexia during hibernation in ground squirrels by inhibiting hypothalamic feeding center sensitivity to hunger signals.

bioRxiv · Mar 15, 2023 · PreprintPhysiology

Zn2+ triggered two-step mechanism of CLIC1 membrane insertion and activation into chloride channels

L. Varela, A. C. Hendry, J. Cassar, R. Martin-Escolano, D. Cantoni, J. C. Edwards, V. B. Abdul-Salam, J. L. Ortega-Roldan

This study identifies Zn2+ binding as the molecular switch for CLIC1 membrane insertion and pH-dependent chloride efflux activation.

bioRxiv · Oct 25, 2021Biochemistry

Membrane insertion of soluble CLIC1 into active chloride channels is triggered by specific divalent cations

L. Varela, A. C. Hendry, E. Medina-Carmona, D. Cantoni, J. L. Ortega-Roldan

This paper identifies Ca2+ and Zn2+ binding as the molecular switch triggering CLIC1 membrane insertion into active chloride channels.

bioRxiv · Oct 2, 2019 · PreprintBiochemistry