H. Cao

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

Hosts Manipulate Lifestyle Switch and Pathogenicity Heterogeneity of Opportunistic Pathogens in the Single-cell Resolution

The paper shows how Drosophila larvae influence the lifestyle and pathogenicity of Serratia marcescens at the single-cell level through transcriptomic and metabolic changes.

Global Sensitivity Analysis of the Onset of Nasal Passage Infection by SARS-CoV-2 With Respect to Heterogeneity in Host Physiology and Host Cell-Virus Kinetic Interactions

This study uses global sensitivity analysis to identify key factors driving variability in SARS-CoV-2 nasal infection outcomes, focusing on host physiology and cell-virus kinetics.

Immunities Specific to Both of the M Protein Ectodomain and RBD Synergize to Confer Cross-protection against SARS-CoV-2 Infections

This study identifies conserved M protein peptides that elicit cross-neutralizing antibodies against multiple SARS-CoV-2 variants, including Omicron, when combined with RBD-specific antibodies.

Consecutive treatments of methamphetamine promote the 4 development of cardiac pathological symptoms in zebrafish

This study investigates the effects of repeated methamphetamine exposure on zebrafish cardiac function, revealing decreased heart rate, increased heart rate variability, and fibrotic changes.

Hypothalamic hormone deficiency enables physiological anorexia

This study shows that thyroid hormone deficiency causes anorexia during hibernation in ground squirrels by inhibiting hypothalamic feeding center sensitivity to hunger signals.

CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

PD-L1 regulates inflammatory macrophage development from human pluripotent stem cells by maintaining interferon-gamma signal

This study shows PD-L1 maintains IFN-gamma signaling in human pluripotent stem cell-derived macrophages, essential for their development and inflammatory function.

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane

The paper reports a cryo-EM structure of the SARS-CoV-2 postfusion spike in a membrane, revealing structural details of membrane-interacting segments.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

Kynurenic acid promotes A1 to A2 astrocyte conversion against HIV-associated neurocognitive disorder

This study shows that kynurenic acid reduces A1 astrocyte activation and promotes A2 astrocyte formation, improving cognitive deficits in HIV-1 gp120 transgenic mice.

Obesity Disrupts Pituitary UPR Leading to NAFLD

This study shows obesity disrupts pituitary UPR, leading to NAFLD, and demonstrates that restoring pituitary UPR can ameliorate metabolic defects.

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

A Low-Cost, 3D-Printed Biosensor for Rapid Detection of Escherichia coli

This paper presents a low-cost, 3D-printed biosensor for rapid detection of specific E. coli strains with high sensitivity and potential for point-of-care use.

Identification of bacteria strains using the Recombinase Polymerase Amplification assay on a miniaturized solid-state pH sensor

This paper develops a miniaturized solid-state pH sensor using RPA to rapidly and sensitively detect bacterial strains with high accuracy.

Protein turnover in the developing Triticum aestivum grain

This study measures protein turnover rates in developing wheat grain using proteomics, revealing spatiotemporal patterns and quantifying the energy costs of protein synthesis and degradation.

The special and general mechanism of cyanobacterial harmful algal blooms

The paper examines the special and general mechanisms of cyanobacterial harmful algal blooms, identifying ecological and evolutionary factors that enable cyanobacteria to dominate under eutrophic conditions.

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

Cardiotoxic effects of methamphetamine associated with electrophysiological and epigenetic aberrations in Zebrafish

This study examines cardiotoxic effects of methamphetamine in zebrafish, finding increased heart rate but not QTc prolongation, along with myocardial damage and gene expression changes.

Simultaneous Cardiac and Neurological Monitoring to Assess Chemical Exposures and Drug Toxicity in Xenopus Laevis

This paper develops a microelectrode array system for real-time ECG and EEG monitoring in Xenopus laevis under chemical exposure, demonstrating its ability to detect drug-induced physiological changes.

Fetal Electrocardiogram Extraction from the Mother's Abdominal Signal Using the Ensemble Kalman Filter

This paper develops an Ensemble Kalman Filter algorithm to extract fetal ECG from single-channel abdominal signals, achieving high accuracy on clinical and benchmark datasets.

A Novel Art of Electrocardiogram Assessment in Zebrafish for Cardiovascular Disease Studies and Drug Screening

This study develops a novel ECG monitoring system for zebrafish to assess cardiovascular function and drug effects, showing improved efficiency and reduced side effects.

The compound of baicalein, wogonin, and oroxylin-A inhibits EMT in A549 cell line via PI3K/AKT-TWIST1-glycolysis pathway

This study identifies baicalein, wogonin, and oroxylin-A as active compounds in TFAE that inhibit EMT in A549 cells via the PI3K/AKT-TWIST1-glycolysis pathway.

Intranasal HD-Ad Vaccine Protects the Upper and Lower Respiratory Tracts of hACE2 Mice against SARS-CoV-2

FEATURE DETECTION TO SEGMENT CARDIOMYOCYTE NUCLEI FOR INVESTIGATING CARDIAC CONTRACTILITY

This paper introduces an improved feature detection framework to segment cardiomyocyte nuclei in zebrafish hearts, enabling quantitative analysis of cardiac contractility across developmental stages.

Automatic segmentation and cardiac mechanics analysis of evolving zebrafish using deep-learning

The paper develops a deep-learning method to segment and analyze cardiac mechanics in developing zebrafish, revealing incremental volume changes in ventricles and stable stroke volume in atria.

A transferrable and integrative type I-F Cascade for heterologous genome editing and transcription modulation

This paper develops a transferrable I-F Cascade system for genome editing and transcription modulation in P. aeruginosa, showing improved efficiency and versatility over Cas9.