Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells
C. F. Magnani, R. Myburgh, S. Brunn, M. Chambovey, M. Ponzo, L. Volta, C. Pellegrino, S. Pascolo, C. Miskey, Z. Ivics, J. A. Shizuru, D. Neri, M. G. Manz
This study develops anti-CD117 CAR T cells with a safety switch to target and eliminate acute myeloid leukemia and hematopoietic stem cells in preclinical models.
bioRxiv · Jun 15, 2023Cancer Biology