Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22
Saumya Y. Maru, Meredith Wetzel, Jacob T. Mitchell, Nicole Groß, Lalitya Andaloori, Kathryn L. Howe, Emma Kartalia, Guanglan Mo, James Leatherman, Won Jin Ho, Elana Judith Fertig, Luciane Tsukamoto Kagohara, Edward J. Pearce, Elizabeth M. Jaffee
This study shows antigen-presenting cancer-associated fibroblasts (apCAFs) in murine pancreatic tumors influence regulatory T cell phenotype and function through CXCL9 and CCL22, affecting immune checkpoint blockade response.
The Journal of Immunology · Jun 1, 2026Peer-reviewedCancer Biology