James M. Leatherman

This study shows antigen-presenting cancer-associated fibroblasts (apCAFs) in murine pancreatic tumors influence regulatory T cell phenotype and function through CXCL9 and CCL22, affecting immune checkpoint blockade response.

The paper investigates how cancer-associated fibroblasts (CAF) influence tumor cell behavior in pancreatic ductal adenocarcinoma by driving EMT and altering cell subtypes, with IL-8 playing a key modulatory role.

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

This study uses spatial multi-omics to identify TLS-associated immune niches in PDAC that correlate with improved survival in immunotherapy responders.

The paper characterizes a novel syngeneic murine breast cancer model (NT2.5-LM) that exhibits rapid and widespread metastases, enabling study of metastatic progression and therapeutic responses.