Establishment of a Long-Term Germ-Free Medaka Model Reveals Microbiota-Dependent Regulation of Growth, Immunity, and Metabolism
Pan‐Pan Jia, Mingfei Wu, Liping Ma, Feng-Yi Guo, Lan-Chen Zhang, Yan Li, De‐Sheng Pei
This study establishes a long-term germ-free medaka model to investigate microbiota-dependent effects on growth, immunity, and metabolism, finding that gut-derived metabolites partially restore developmental and immune deficits but not long-term survival.
bioRxiv · Mar 10, 2026 · PreprintMicrobiology