SCALE: Scalable Conditional Atlas-Level Endpoint transport for virtual cell perturbation prediction
Shuizhou Chen, Lang Yu, Kedu Jin, Xinjie Mao, Songming Zhang, Xinyu Gu, Sheng Xu, Lei Bai, Quan Qian, Qin Chen, Qiang Gao, Siqi Sun, Zhangyang Gao
A set-aware latent transport model predicts treated cell populations from unpaired controls, keeps perturbation-specific signal in CRISPR, drug and cytokine data, and guided a cytokine choice tested in three donors.
bioRxiv · Sep 3, 2026 · PreprintCell Biology✦ In-depth digest