Larry Cameron Liles

Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease

This study shows that pathogenic tau in the locus coeruleus causes hyperactivity and neuropsychiatric symptoms similar to early Alzheimer's disease in mice.

Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice

This study shows that dopamine β-hydroxylase knockout in mice alters innate responses to predator odor, with reduced defensive burying and increased grooming, suggesting NE and DA balance regulates behavioral responses.

The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease

This study uses DSP-4 to model early LC-NE system changes in AD and PD, showing axon damage, neuroinflammation, and behavioral changes without LC cell death.

Genetic loss of norepinephrine does not alter adult hippocampal neurogenesis in dopamine β-hydroxylase deficient mice

The paper investigates the effect of genetic NE loss on adult hippocampal neurogenesis and finds no difference in progenitor proliferation or survival in Dbh-/- mice, contrasting with pharmacological NE depletion.

Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

The paper investigates how norepinephrine and dopamine influence distinct repetitive behaviors in mice exposed to novel odorants, showing differential effects on digging and grooming.

Co-released Norepinephrine and Galanin Act on Different Timescales to Promote Stress-Induced Anxiety-Like Behavior

This study investigates the distinct roles of norepinephrine and galanin in stress-induced anxiety-like behavior using genetic and pharmacological approaches in mice.

Chronic environmental or genetic elevation of galanin in noradrenergic neurons confers stress resilience in mice

This study shows chronic exercise and genetic overexpression of galanin in noradrenergic neurons increase stress resilience in mice by enhancing galanin expression in the locus coeruleus.

Noradrenergic circuits in the forebrain control affective responses to novelty

This study investigates the role of central norepinephrine in novelty-induced behaviors, finding that NE signaling is essential for both neophilic and neophobic responses.

Central norepinephrine transmission is required for stress-induced repetitive behavior in two rodent models of obsessive-compulsive disorder

The paper investigates the role of norepinephrine in stress-induced repetitive behaviors in OCD models, finding that NE deficiency reduces compulsive behaviors and that restoring NE rescues these behaviors.

Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors

This study shows that eliminating galanin in noradrenergic neurons reduces galanin in specific brain regions and alters coping behaviors without affecting norepinephrine levels.

Loss of β-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids

This study shows that loss of β-arrestin2 in D2 neurons reduces dopamine inhibition of D2-MSNs and alters behavioral responses to psychostimulants and opioids, while having minimal effect on D1 neurons.

The Norepinephrine Metabolite DOPEGAL Confers Locus Coeruleus Tau Vulnerability and Propagation via Asparagine Endopeptidase

The paper identifies DOPEGAL as a factor that promotes Tau pathology and propagation in locus coeruleus neurons via AEP cleavage of Tau.