Fredric P. Manfredsson

Dual kinase inhibition provides early clues to restoration of neuroimmune homeostasis in an AAV-haSyn model of Parkinsons disease

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation

The paper investigates the role of MHCII reduction in protecting mice from alpha-synuclein-induced degeneration and finds that it is insufficient, while showing epigenetic regulation of the Parkinson's HLA locus.

Devaluing memories of reward: A case for dopamine

This study identifies dopamine's role in devaluing reward memories through experimental and computational methods, showing its necessity for mediated devaluation and hedonic evaluation reduction.

Tau, amyloid-beta and alpha-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology

This paper shows that combined Alzheimer's and Parkinson's protein pathologies enhance neuroinflammation and neurodegeneration in a mouse model.

Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy.

This study investigates the role of CD8+ T cells in a mouse model of multiple system atrophy and finds they are not critical for disease progression but modulate neuroinflammation and demyelination.

Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling

This study examines changes in GDNF receptor expression in the striatum and substantia nigra following a nigrostriatal lesion in rats, finding differential expression patterns of GFR-1 and RET that may impact GDNF therapeutic efficacy.

Nicotine-mediated recruitment of GABAergic neurons to a dopaminergic phenotype attenuates motor deficits in alpha-synuclein Parkinson's model.

This study shows nicotine promotes GABAergic neurons to adopt a dopaminergic phenotype, reducing alpha-synuclein-induced motor deficits in Parkinson's models.

Nigral-specific increase in ser31 tyrosine hydroxylase phosphorylation offsets dopamine loss and forestalls hypokinesia onset during progressive nigrostriatal neuron loss

The paper investigates how increased ser31 tyrosine hydroxylase phosphorylation in the substantia nigra compensates for dopamine loss and delays hypokinesia onset in a rat model of Parkinson's disease.

IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophy

This study shows that IFNγ from CD4+ T cells drives neuroinflammation and demyelination in a mouse model of MSA.

Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson’s Disease

This study shows that overexpressing Nurr1 in the striatum of rats induces LID and worsens dyskinesia, suggesting Nurr1 as a therapeutic target for Parkinson’s disease.

Dorsal raphe oxytocin receptors regulate the neurobehavioral consequences of social touch

This study shows that oxytocin receptors in the dorsal raphe regulate serotonin-induced cortical plasticity, affecting prosocial behaviors in mother rats.

α-synuclein aggregates induce c-Abl activation and neurodegeneration by a redox stress mechanism

This study shows that α-synuclein aggregates cause c-Abl activation via redox stress, leading to neurodegeneration, and that N-acetyl cysteine can block this process in Parkinson's disease models.

The Norepinephrine Metabolite DOPEGAL Confers Locus Coeruleus Tau Vulnerability and Propagation via Asparagine Endopeptidase

The paper identifies DOPEGAL as a factor that promotes Tau pathology and propagation in locus coeruleus neurons via AEP cleavage of Tau.