Author

Lars Joenson

F. Hoffmann-La Roche AG

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:multiome· 1 Organism:non-human primate· 1

Frequent Co-Authors

Erich KolleriD· 2 shared Annamaria Braendli-Baiocco· 1 shared Azad BonniiD· 1 shared Charlotte BoniD· 1 shared Congwei WangiD· 1 shared Danièle Buchy· 1 shared Disa TehleriD· 1 shared Joerg F. HippiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Erich KollerORCID

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Author profile →

3 papers

Recent·Most cited

Antisense oligonucleotides targeting transcription termination windows disrupt mRNA 3' end processing and decrease gene expression

Kinga Winczura, Lars Joenson, Erich Koller, Pawel Grzechnik, Lukasz Jan Kielpinski

This study shows that antisense oligonucleotides targeting transcription termination windows can decrease gene expression by disrupting mRNA 3' end processing and causing off-target effects.

Nature Communications · Oct 9, 2026Peer-reviewedMolecular Biology

Cell-Type Specific Molecular and Functional Consequences of TDP-43 Loss-of-Function in Human Induced Neurons

Vera Gysin Filippa, Karsten Bach, Vitaliy Kolodyazhniy, Lars Joenson, Marcos Romualdo Costa

This study examines the molecular and functional effects of TDP-43 loss in human induced neurons, revealing cell-type-specific gene expression and splicing changes, and a hyperexcitable phenotype in both glutamatergic and cholinergic motor neurons.

bioRxiv · Jan 28, 2026 · PreprintNeuroscience

Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey

Ravi Jagasia, Charlotte Bon, Soren V. Rasmussen, Solveig Badillo, Disa Tehler, Danièle Buchy, Marco Berrera, Megana K. Prasad, Marco Terrigno, Nikhil Janak Pandya, Veronica Costa, Congwei Wang, Lykke Pedersen, Meghan T. Miller, Kamille Dumong Erichsen, , Marius Christian Hoener

The paper identifies a potent ASO targeting UBE3A-ATS in Angelman syndrome patient neurons, showing long-lasting effects in cynomolgus monkeys.

bioRxiv · Jun 9, 2022 · PreprintNeuroscience