Purkinje cell intrinsic activity shapes cerebellar development and function
Catarina Osório, Joshua J. White, Paula Torrents-Solé, Jie Yang, Nienke Mandemaker, Federico Olivero, Freya Kirwan, Laura C. Post, Zahra Hemmat, Fred de Winter, Eleonora Regolo, Francesca Romana Fiocchi, Ines Serra, Saffira Tjon, Zeliha Özgür, , Martijn Schonewille
This study shows that Purkinje cell intrinsic activity before synaptic maturation is critical for dendrite growth, connectivity, and cerebellar function, with early disruptions causing severe morphological and functional defects.
Nature Communications · Mar 9, 2026Peer-reviewedNeuroscience