Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice
Heidi M. Blank, Staci E. Hammer, Laurel Boatright, Courtney Roberts, Katarina E. Heyden, Aravindh Nagarajan, Mitsuhiro Tsuchiya, Marcel Brun, Charles D. Johnson, Patrick J. Stover, Raquel Sitcheran, Brian Keith Kennedy, L. Garry Adams, Matt R. Kaeberlein, Martha S. Field, , Michael Polymenis
This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.
bioRxiv · Jan 12, 2024 · PreprintMolecular Biology