Mitsuhiro Tsuchiya

PU.1 inhibition sensitizes stem-monocytic AML to BCL2 blockade

This study identifies stem-monocytic AML as a distinct subtype resistant to venetoclax and shows that PU.1 inhibition synergizes with BCL2 blockade to enhance therapeutic response.

Mutant ASXL1 Drives Transcriptional Activation and Repression in Human Hematopoiesis

This study functionally characterizes mutant ASXL1 in human hematopoietic stem cells, showing it drives transcriptional activation and repression through interactions with BRD4 and MECOM, with implications for therapy.

Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice

This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.

Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function

The paper shows that reducing Cth2 activity in yeast increases lifespan by improving mitochondrial function through reduced repression of iron-related genes.

A prion accelerates proliferation at the expense of lifespan

This study shows that the prion [BIG+] in yeast increases proliferation but reduces lifespan by altering protein synthesis and translational programs.

Translational control of methionine and serine metabolic pathways underpin the paralog-specific phenotypes of Rpl22 ribosomal protein mutants in cell division and replicative longevity

The paper identifies translational control of methionine and serine metabolic pathways as the mechanism underlying paralog-specific phenotypes in Rpl22 ribosomal protein mutants, linking these changes to cell division and replicative longevity.

Phenotypic and genotypic consequences of CRISPR/Cas9 editing of the replication origins in the rDNA of Saccharomyces cerevisiae

This study edits rDNA replication origins in yeast using CRISPR/Cas9, revealing growth and lifespan consequences of such modifications.