Soluble ZP2 N-terminal fragments activate CatSper-dependent Ca2+ entry and regulate motility and acrosomal exocytosis in mammalian sperm
Caroline Wiesehöfer, Lorena Sunjic, Lara Suetin, Jong‐Nam Oh, Marc Wiesehoefer, Mykola Lyndin, Thiviya Thayaparan, Layani Chandrakumar, Jean‐Ju Chung, Gunther Wennemuth
This study identifies soluble ZP2 N-terminal fragments as activators of CatSper-dependent Ca2+ entry, regulating sperm motility and acrosomal exocytosis in mice and humans.
bioRxiv · Aug 20, 2026 · PreprintCell Biology