Author

Lei Lei

Haverford College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biochemistry· 2 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:GWAS summary statistics· 1 Organism:human· 1

Frequent Co-Authors

Uria Alcolombri· 2 shared Bingbing Dai· 1 shared Chang Liu· 1 shared Dan S Tawfik· 1 shared Dan S. Tawfik· 1 shared Daniel R. SchrideriD· 1 shared Diana Meltzer· 1 shared Dylan D. RayiD· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

Uria Alcolombri

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Author profile →

4 papers

Recent·Most cited

Interpreting Convolutional Neural Networks in Population Genetics

Huiting Xu, Leon Zong, Dylan D. Ray, Lei Lei, Daniel R. Schrider, Franz Baumdicker, Sara Mathieson

This study investigates how convolutional neural networks in population genetics implicitly compute summary statistics and reveals their ability to efficiently approximate long-range linkage disequilibrium.

Molecular Biology and Evolution · Oct 1, 2026Peer-reviewedGenomics

Altered Bacteria-Fungi Inter-Kingdom Network in Gut of Ankylosing Spondylitis Patients

Ming Li, Bingbing Dai, Yawei Tang, Lei Lei, Ningning Li, Chang Liu, Teng Ge, Lilong Zhang, Yao Xu, Yuqi Hu, Pengfei Li, Yan Zhang, Jieli Yuan, Xia Li

This study identifies altered fungal and bacterial interactions in the gut microbiota of Ankylosing Spondylitis patients using 16S rDNA and ITS2 sequencing.

bioRxiv · Aug 21, 2018 · PreprintMicrobiology

Native or promiscuous? Analyzing putative dimethylsulfoniopropionate lyases using a substrate proofing approach

Lei Lei, Kesava Phaneendra Cherukuri, Diana Meltzer, Uria Alcolombri, Dan S. Tawfik

The paper distinguishes native DMSP lyases from promiscuous ones using substrate profiling, finding that high activity and sensitivity to structural changes indicate native function, while low activity and crossreactivity suggest promiscuity.

bioRxiv · Jul 27, 2017 · PreprintBiochemistry

DddY is a bacterial dimethylsulfoniopropionate lyase representing a new cupin enzyme superfamily with unknown primary function

Lei Lei, Uria Alcolombri, Dan S Tawfik

This paper characterizes DddY, a bacterial DMSP lyase with cupin motifs, showing it requires a metal cofactor and belongs to a new Cupin-DLL superfamily with unknown primary function.

bioRxiv · Jul 9, 2017 · PreprintBiochemistry