Lei Zhao

CMS: Achieving Uniform and High-Quality Sequencing across Challenging Non-canonical Genomic Regions

CMS improves sequencing uniformity and accuracy in non-canonical genomic regions by optimizing chemistry and enzymatic systems, reducing low-coverage bins and false negatives.

A novel virus vB_PshM_Y4 with low similarity to both cultured and uncultured viruses

This study isolates and characterizes a novel virus, vB_PshM_Y4, showing it is not detectable by high-throughput sequencing and belongs to an unknown viral family.

Antisense transcription and its roles in adaption to environmental stress in E. coli

This study identifies 660 antisense RNAs in E. coli K12 under various culture conditions and shows their role in regulating gene expression during environmental stress.

Corilagin controls post-parasiticide schistosome egg-induced liver fibrosis by inhibiting Stat6 signalling pathway

This study shows Corilagin reduces liver fibrosis caused by schistosome eggs by inhibiting the Stat6 signaling pathway in vitro and in vivo.

Mass spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: Comparison to IHC and FISH

This study compares mass spectrometry-based Her2 quantitation to IHC and FISH in gastroesophageal tumors, finding high concordance and improved specificity.

Resolving the conflict between associative overdominance and background selection

The paper analyzes the conditions under which genetic variability at a neutral locus linked to a selected locus is retarded or accelerated, showing that background selection dominates when S is large, while associative overdominance can still occur with partially recessive mutations.