Fan Yang

m6A-dependent microRNA binding to chromatin-associated RNA for transcriptional activation

The paper reveals an m6A-dependent mechanism where microRNAs bind chromatin-associated RNAs to activate transcription by recruiting chromatin remodelers and demethylases.

Polymerization of Tetraspanin 7 into Helical Transmembrane Skeletons for Tubular Membrane Stabilization

The paper identifies TSPAN7's role in forming helical transmembrane structures that stabilize tubular membrane protrusions by sensing curvature and resisting mechanical stress.

Cortactin regulates metastatic dormancy of circulating tumor cells by suppressing mTOR-dependent senescence

This study identifies cortactin's role in suppressing mTOR-dependent senescence in CTCs, leading to metastatic dormancy, and proposes a therapeutic strategy combining cortactin depletion and senolytics.

Distribution-preserved compression of single-cell atlases for privacy-protected data dissemination and novel cell type discovery

SUREv2 compresses single-cell atlases while preserving distribution, enabling privacy-protected data sharing and novel cell type discovery.

Cellular and molecular events organizing the assembly of tertiary lymphoid structures in glioblastoma

This study identifies cellular and molecular mechanisms of tertiary lymphoid structure (TLS) formation in glioblastoma, showing TLS correlate with improved survival and are driven by CD4 T cells expressing lymphotoxin β.

Exploring the mechanisms and potential therapeutic targets of Ferroptosis Related Genes in ankylosing spondylitis

This study identifies 20 ferroptosis-related genes associated with ankylosing spondylitis using bioinformatics analysis and suggests targeting ferroptosis as a potential therapeutic strategy.

Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2

This study examines B cell clonal expansion and convergent antibody responses in SARS-CoV-2 patients, identifying shared features with SARS-CoV.

Single-molecule optical mapping enables quantitative measurement of D4Z4 repeats in facioscapulohumeral muscular dystrophy (FSHD)

This paper develops a single-molecule optical mapping method for quantitative D4Z4 repeat analysis in FSHD, showing concordance with Southern blot and improved haplotype resolution.

Microbial Cells Harboring a Mitochondrial Gene Are Capable of CO2 Capture

This study identifies a mitochondrial gene, OG1, capable of CO2 capture in engineered microorganisms, suggesting its potential for mitigating global warming through biological CO2 capture in barren lands.

Corilagin controls post-parasiticide schistosome egg-induced liver fibrosis by inhibiting Stat6 signalling pathway

This study shows Corilagin reduces liver fibrosis caused by schistosome eggs by inhibiting the Stat6 signaling pathway in vitro and in vivo.

Effects of Xiantao sewage treatment on microbial community structure of shallow groundwater in wetland

This study examines how Xiantao sewage treatment affects microbial communities in shallow groundwater by analyzing environmental factors and microbial diversity using Illumina Miseq sequencing.

Estrogen represses Tgfbr1 and Bmpr1a expression via estrogen receptor beta in MC3T3-E1 cells

This study shows estrogen represses Tgfbr1 and Bmpr1a via ER beta in MC3T3-E1 cells, using RNA sequencing and ChIP analysis.

RefSoil: A reference database of soil microbial genomes

The paper curates a soil microbial genome database (RefSoil) to improve annotation of soil metagenomes and identifies underrepresented taxa for future sequencing.