Author

Leilei Tu

First Affiliated Hospital of Jinan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jiang-Hui WangiD· 3 shared Alex William HewittiD· 2 shared Guei‐Sheung LiuiD· 2 shared Raymond C.B. WongiD· 2 shared Vicki ChrysostomouiD· 2 shared Vikrant Singh· 2 shared Alex Hewitt· 1 shared Alice Pebay· 1 shared

Activity by Year

2016-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMolecular Biology

Jiang-Hui WangORCID

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Author profile →

3 papers

Recent·Most cited

MicroRNA-143 plays a protective role in ischemia-induced retinal neovascularization

Jiang-Hui Wang, Yu-Fan Chuang, Jinying Chen, Vikrant Singh, Fan‐Li Lin, Richard Wilson, Leilei Tu, Chenkai Ma, Raymond C.B. Wong, Peng‐Yuan Wang, Jingxiang Zhong, Alex William Hewitt, Peter van Wijngaarden, Gregory James Dusting, Guei‐Sheung Liu

The paper identifies miR-143 as a protective miRNA in ischemia-induced retinal neovascularization using miRNA-Seq and RNA-Seq in a rat model.

Nucleic Acid Therapeutics · Apr 1, 2022Peer-reviewedMolecular Biology

Efficacy and dynamics of self-targeting CRISPR/Cas constructs for gene editing in the retina.

Li Fan, Sandy S. C. Hung, Mohd Khairul Nizam Mohd Khalid, Jiang-Hui Wang, Vicki Chrysostomou, Vickie H. Y. Wong, Vikrant Singh, Kristof Wing, Leilei Tu, James A. Bender, Alice Pébay, Anna Elizabeth King, Anthony L. Cook, Raymond C.B. Wong, Bang Viet Bui, , Guei‐Sheung Liu

This study develops a self-destructing CRISPR/Cas system for retinal gene editing, showing reduced SpCas9 mRNA and improved safety without compromising on-target efficiency.

Human Gene Therapy · Aug 2, 2019Peer-reviewedGenetics

AAV-mediated CRISPR/Cas gene editing of retinal cells in vivo.

Sandy SC Hung, Vicki Chrysostomou, Amy Fan Li, Jeremiah KH Lim, Jiang-Hui Wang, Joseph E Powell, Leilei Tu, Maciej Daniszewski, Camden Lo, Raymond C Wong, Jonathan G Crowston, Alice Pebay, Anna E King, Bang V Bui, Guei-Sheung Liu, Alex Hewitt

This study uses AAV2 to deliver CRISPR/Cas components to retinal cells in Thy1-YFP mice, achieving an 84% reduction in YFP-positive cells without affecting retinal function.

Investigative Opthalmology & Visual Science · Jun 29, 2016Peer-reviewedGenomics