A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesis
Yu Zhang, Yaqing Zhang, Chengyu LIU, Wenlin Ren, Chenhao Li, Yongqi Guo, Leyi Bai, Peigang Wang, Jing An, Jun Liu, Qiang Ding
This study identifies a single residue in ZIKV NS5 that modulates immune evasion, viral replication, and pathogenesis by affecting STAT2 degradation and IFN signaling.
bioRxiv · Jan 1, 2026 · PreprintMicrobiology