Yu Zhang

LysM: a bacterial self-encoded peptidoglycan hydrolase as an antimicrobial and anti-biofilm agent for Gram-negative nosocomial pathogens

This paper identifies LysM, a bacterial enzyme with broad-spectrum antimicrobial and anti-biofilm activity against Gram-negative pathogens, and shows it can enhance antibiotic efficacy.

Attenuated Salmonella-Mediated Delivery of GSDMD Potentiates PD-1 Blockade Therapy against Melanoma

This study combines attenuated Salmonella-delivered GSDMD with anti-PD-1 therapy to enhance anti-melanoma immune responses in mice.

Multi-parametric NIR-II fluorescence perfusion imaging towards quantitative stroke evaluation

This paper introduces FIMPA, a framework for multi-parametric NIR-II fluorescence perfusion imaging to quantitatively evaluate stroke, validated in mice.

FlashBind: Towards Accurate and Efficient Structure-based Virtual Screening

FlashBind improves drug discovery by offering faster and accurate protein-ligand interaction predictions compared to Boltz-2, with real-world validation in antibiotic screening.

Lineage recording reveals hijacked hepatic progenitor states as a common origin of HCC and ICC

The paper uses CERAMIC to trace liver tumor initiation, identifying Hep_Bi-zonal cells as the origin of HCC and ICC and revealing peroxisomal metabolism and macrophage niches as key factors.

Hidden genetic diversity in 320 nearly-complete East Asian genome assemblies

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

Annual life-history strategy hitchhikes low-light adaptation in a clonal seagrass

The paper shows that annual life-history strategy in seagrass is linked to low-light adaptation through genetic coupling of SAPK7 and CAO genes.

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T cell responses during chronic viral infection

This study shows that targeting IL-2 to antigen-specific CD8 T cells enhances their responses during chronic viral infection while sparing non-targeted populations, and combining this with PD-1 blockade further improves outcomes.

The HOG MAPK - Transcription Factor CsAtf1 - CsErg5B Regulatory Module Mediates Conidial Germination and Fludioxonil Sensitivity in Colletotrichum siamense

An autonomous LLM agent platform for computational binder design and conjugation-aware prioritization of antibody drug conjugates

This paper introduces an autonomous LLM agent platform for computational binder design and ADC prioritization, achieving accurate classification across oncology targets with minimal human intervention.

Exploration of Orally Disintegrating Tablet for Sublingual Vaccination against Mucosal Bacterial Infection

This study develops a sublingual vaccine tablet that induces strong sIgA responses and protects against periodontitis in mice and non-human primates.

Nanosecond laser-driven proton FLASH spares normal tissue cells by sustaining mitochondrial homeostasis and attenuating ferroptosis

This study shows that nanosecond laser-driven proton FLASH-RT spares normal tissue by preserving mitochondrial homeostasis and reducing ferroptosis, while maintaining tumor-killing efficiency.

HMA proteins produce 2',3'-cNMP signaling molecules and activate CNL-mediated immunity in rice

This study identifies HMA proteins in rice as sensors that generate 2',3'-cNMP signaling molecules, which are perceived by CNL LRR domains to activate immunity against blast disease.

miRNA/mRNA analysis of increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiation

The paper analyzes miRNA and mRNA expression in endometrial biopsies to show increased TGF-β pathways drive EMT and Treg differentiation in Chlamydia infection.

Structural Basis for Cas9-Directed Spacer Acquisition in Type II-A CRISPR-Cas Systems

This study reveals the structural dynamics of Cas9-mediated spacer acquisition in Type II-A CRISPR-Cas systems through cryo-EM analysis of the Cas9-Csn2-Cas1-Cas2 complex.

Insomnia-Related Metabolomic Profiles Reflect Antioxidant Deficits and Relate to Cognitive Decline Through a Metabolic Risk Score in HCHS/SOL

This study identifies metabolites linked to insomnia symptoms and develops risk scores predicting cognitive decline in Hispanic/Latino adults.

Enhancing interpretability of cryo-EM maps with hybrid attention Transformers

This paper introduces DEMO-EMReF, a Transformer-based framework for refining cryo-EM density maps, improving resolution and atomic model accuracy.

Dual-Mode Microfluidic Immunostaining (Dumi) Device for Diagnostic Biomarkers Detection and Tumor Microenvironment Evaluation

The paper introduces a microfluidic device that reduces tissue usage for immunostaining and TME analysis in rare tumors, achieving >90% reduction in section usage and enabling comprehensive biomarker detection.

A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesis

This study identifies a single residue in ZIKV NS5 that modulates immune evasion, viral replication, and pathogenesis by affecting STAT2 degradation and IFN signaling.

Spatially barcoding biochemical reactions using DNA nanostructures unveil a major contact mechanism in proximity labeling

The paper uses DNA nanostructures to measure the labeling radii of TurboID and APEX2, revealing contact-dependent mechanisms rather than diffusive labeling.

Web engine for tumor pathology image retrievals on massive scales

HERE is an image retrieval engine for H&E tumor pathology images that uses AI encoding and indexing to efficiently find similar images across large datasets.

Acute stress impairs target enhancement rather than distractor suppression in attention selection: Evidence from the N2pc and PD

This study investigates how acute stress affects attention selection by comparing target enhancement and distractor suppression using event-related potentials and a visual search task.

Programmable Aptamer-Embedded Circular RNAs for Targeted Antigen-Presenting Cells Immunotherapy

This paper develops Apt-circRNAs for targeted antigen-presenting cell immunotherapy, showing efficacy in tumors and clinical trials.

Expression screening and functional verification of recombinant hirudin from novel chassis cell Chlamydomonas reinhardtii

This paper produces functional hirudin in Chlamydomonas reinhardtii, demonstrating high thrombin-inhibitory activity and safety in a murine model.

Triple-effect correction for Cell Painting data with contrastive and domain-adversarial learning

The paper introduces cpDistiller, a method to correct three technical effects in Cell Painting data using contrastive and domain-adversarial learning, improving analysis reliability and phenotypic response detection.

LSH-mediated resolution of R-loops mitigates transcription-replication conflicts to preserve genomic stability in prostate cancer cells

This study shows LSH resolves R-loops in prostate cancer cells, reducing transcription-replication conflicts and DNA damage, and identifies LSH as a potential therapeutic target.

A curated collection of transcriptome datasets to study the transcriptional response in blood and nasal samples following viral respiratory inoculation and vaccination

The paper curates a collection of transcriptome datasets from viral respiratory inoculation and vaccination studies to enable reanalysis of transcriptional responses in blood and nasal samples.

Highly divergent mesnidoviruses found in TSA database, especially in spiders

The paper reports 18 newly discovered mesnidoviruses in the TSA database, mostly from spiders, showing high divergence and suggesting new species or higher taxa.

Comprehensive Assessment of Ischemic Stroke in Nonhuman Primates: Neuroimaging, Behavioral, and Serum Proteomic Analysis

This study assesses ischemic stroke in nonhuman primates using neuroimaging, behavioral analysis, and serum proteomics to identify biomarkers and understand stroke pathophysiology.

Structural basis of translation in transcription-translation coupling

The paper reports cryo-EM structures of transcription-translation complexes (TTCs) at different stages of the translation cycle in E. coli, revealing structural changes and their functional implications.