Reactivation of a TAL1 progenitor cell enhancer region by non-coding somatic variants in T-lineage acute lymphoblastic leukemia
Nadezhda V. Terekhanova, Xiaolong Chen, Kin-Hoe Chow, Yu Liu, Ying Shao, Li Dong, Bensheng Ju, Vinesh Vinayachandran, Haseeb Zubair, Kohei Hagiwara, Wentao Yang, X X, Sivaraman Natarajan, John B. Easton, David T. Teachey, , Jinghui Zhang
The paper identifies non-coding somatic variants in TAL1 regulatory regions that reactivate enhancers normally active in hematopoietic stem cells in T-lineage acute lymphoblastic leukemia.
bioRxiv · May 6, 2026 · PreprintCancer Biology