Author

Steven Burden

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Virginia A. ValentineiD· 4 shared Seth StalleriD· 3 shared John B. EastoniD· 2 shared Alaguraj VeluchamyiD· 1 shared Alfred Thomas LookiD· 1 shared Bensheng JuiD· 1 shared Brett Brown· 1 shared Brian J. AbrahamiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBioinformatics

Virginia A. ValentineORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Glucocorticoid receptor activation reorganizes Wnt/LEF1 regulatory circuitry associated with therapeutic response in B-cell acute lymphoblastic leukemia

Robert J. Mobley, Damilola Oluwalana, Gabriele Baniulyte, Minzhang Zheng, Brett Brown, Faten Usrof, Kashi Raj Bhattarai, Kelly R. Barnett, Virginia A. Valentine, Marcus L Valentine, Seth Staller, Satoshi Yoshimura, Kristine R. Crews, David T Teachey, Steven Burden, , Daniel Savic

This study shows that GR activation reorganizes Wnt/LEF1 regulatory circuitry in B-ALL, influencing therapeutic response and resistance through chromatin state changes and gene regulation.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology

zFISHer: Automated 3D Registration, Detection, and Colocalization with Interactive Curation for Sequential Multiplexed FISH

Seth Staller, Virginia A. Valentine, Steven Burden

bioRxiv · May 21, 2026 · PreprintBioinformatics

3D-super-enhancers are condensate-associated cis-regulatory communities

Jie Lv, Kelsey A. Maher, Li Dong, Virginia A. Valentine, Seth Staller, Alaguraj Veluchamy, Li Tian, Yuna Kim, Bensheng Ju, M B Valentine, John B. Easton, Stanley B Pounds, Steven Burden, Brian J. Abraham

The paper introduces BOUQUET, an algorithm that identifies 3D-super-enhancers as protein-rich cis-regulatory communities associated with co-activator condensates in mammalian cells.

Nucleic Acids Research · Feb 24, 2026Peer-reviewedMolecular Biology

Seq2Karyotype (S2K): A Method for in-silico Karyotyping Using Single-Sample Whole-Genome Sequencing Data

Limeng Pu, Karol A. Szlachta, Virginia A. Valentine, Meiling Jin, Sivaraman Natarajan, Robert Greenhalgh, Nadezhda V. Terekhanova, Jian Wang, Daniel K. Putnam, Li Dan Dong, Lingxiang Jiang, Soumya Tumbath, Xiumei Huang, Xiaotu Ma, Alfred Thomas Look, , Jinghui Zhang

Seq2Karyotype (S2K) enables in-silico karyotyping from whole-genome sequencing data, revealing intratumoral heterogeneity and evolutionary trajectories in cancer samples.

bioRxiv · Aug 25, 2025 · PreprintBioinformatics