Li Tian

Structural Evolution of Neural Networks during Zebrafish Early Development

The paper uses live-cell imaging to study neural network development in zebrafish, revealing conserved structural dynamics and optimization strategies.

Neural Innervation Invigorates Yolk Sac Biological Functions beyond Nutrient Reservoir during Zebrafish Embryo Development

The paper reveals that neural innervation transforms the zebrafish yolk sac from a nutrient reservoir into a functional hub coordinating neural, vascular, and metabolic activities during early development.

Hypoxia Promotes Wound Healing via Dynamical-Mechanical Balance and Adhesion Remodeling

This study shows hypoxia accelerates wound healing by altering cell-cell and cell-matrix adhesion dynamics through DSG2 downregulation and ITGB3 biphasic regulation.

Green genetically encoded IP3 biosensor for hierarchical analysis of its signaling network

The paper develops a genetically encoded green fluorescent IP3 biosensor for detecting IP3 signals across concentrations and visualizing its signaling network with cAMP and Ca2+.

Impaired mitochondrial stress signaling mediates bone loss in male mice in the absence of BNIP3.

This study shows that BNIP3 and mitophagy are essential for mitochondrial stress relief during osteoblast differentiation, which is necessary for maintaining bone mass in male mice.

3D-super-enhancers are condensate-associated cis-regulatory communities

The paper introduces BOUQUET, an algorithm that identifies 3D-super-enhancers as protein-rich cis-regulatory communities associated with co-activator condensates in mammalian cells.

Neurogenesis Leads Early Development in Zebrafish

This study uses live-cell imaging in zebrafish to reveal the precise orchestration of early neurogenesis, including axon development and functional maturation.

SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

This study identifies host E3 ubiquitin ligases UBR5 and MARCHF7 that ubiquitinate and degrade SARS-CoV-2 nsp16, inhibiting viral replication across strains.

Hypoxia Promotes Early Tumorigenesis through Dynamical-Mechanical Balance and Genetic Instability

This study shows hypoxia accelerates early tumorigenesis by promoting 3D spheroid fusion through actin dynamics and mechanical balance, while inducing genetic instability via micronuclei and aneuploidy.