Liang Yang

Convergent and divergent phenotypic impacts of estradiol on neurodevelopmental disorder risk genes

The paper evaluates estradiol's effects on ASD/NDD genes using human neurons and zebrafish, finding both convergent transcriptomic effects and gene-specific cellular and behavioral rescue.

immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

The αβTCR repertoire at scale in the immgenT dataset

The paper analyzes the αβTCR repertoire across 734 mouse samples to uncover patterns in TCR diversity, non-random joining, and clonal expansion.

Functional activation reveals a repressor-gated fourth type VI secretion system in clinical Pseudomonas aeruginosa

The paper identifies and characterizes a fourth type VI secretion system (H4-T6SS) in Pseudomonas aeruginosa, showing it is repressor-gated and contributes to inter- and intraspecific antagonism.

Genomic Specificity of Anti-TCR mAbs determined by single-cell RNAseq

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

Expansion of mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Deep genomic models of allele-specific measurements

This paper introduces DeepAllele, a deep learning model for allele-specific gene regulation analysis, showing improved detection of cis-regulatory elements in F1 hybrid mice immune cells.

Interplay between cytokine and FGF2 signaling in induction of entosis and vasculogenic mimicry response in glioblastoma

This study investigates the role of cytokine and FGF2 signaling in inducing entosis and vasculogenic mimicry in glioblastoma, linking macrophage activity to alternative vascularization mechanisms.

RetS senses neurotransmitter norepinephrine and adrenergic agents to regulate Pseudomonas aeruginosa virulence

The paper identifies RetS as a bacterial adrenergic receptor in P. aeruginosa that responds to norepinephrine and dronedarone, modulating virulence and pathogenesis.

A bone-derived protein primes rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons

This paper shows that osteocalcin primes rapid visual escape via GPR37 in VTA GABAergic neurons by reducing K+ currents through cAMP and THIK-1 suppression.

Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

This study uses morphogen gradients in organoids to generate human brain neuronal lineages and identifies interindividual variability in response to these signals.