Samantha M. Borys

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

The paper establishes immgenT-CD8 as a comprehensive reference for mouse CD8αβ T cell differentiation states across diverse immunological contexts.

This study shows PD-1 in CD4+ T cells balances antiviral defense and neuroinflammation during polyomavirus CNS infection by modulating CD8+ T cell responses.

The paper identifies PD-1 deficiency in mice leads to increased CD8+ T cells in the submandibular gland, resembling immune-related adverse events, and shows NK cells regulate these cells via the PD-1/PD-L1 axis.

This paper optimizes AsCas12a for combinatorial genetic screens in human cells by improving on-target and off-target activity and enabling higher-order multiplexing.