Lysosomal abundance in young and aged mouse hearts assessed by In Vivo Imaging Systems (IVIS) Lysotracker imaging and autophagy-related gene expression
Jawaher Albulushi, Hannah Coghlan, Mohesh Moothanchery, Aiswarya Dev, Emily Akerman, Jasmine Heenan, Nordine Helassa, Oluwatobi Samuel Adegbite, Parveen Sharma, Fenil Patel, Libby Harrison, Mahon L. Maguire, Gary R. Mirams, Pawel Sweitach, Harish Poptani, Rebecca A.B. Burton
The paper uses IVIS Lysotracker imaging and RT-qPCR to assess lysosomal abundance and autophagy-related gene expression in young and aged mouse hearts, finding preserved acidic-vesicle pool and stable gene expression.
bioRxiv · Feb 17, 2026 · PreprintPhysiology