Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition
Qiong Wang, Xiangyi Kong, Hongming Song, Li Wang, Lingrui Li, Xiaonan Hou, Santosh Renuse, Muhammad Saddiq Zahari, Ran Cheng, Mahmood Khan, Jidong Wang, Kiran Kumar Mangalaparthi, Lin Fang, Tamara Levin Lotan, Ben Ho Park, , Xinyan Wu
This study identifies Src-mediated upregulation of EphA2 in PTEN-deficient cells and shows that combined AKT and Src inhibition synergistically suppresses tumor growth.
Molecular & Cellular Proteomics · Oct 22, 2025Peer-reviewedCancer Biology