Akhilesh Pandey

The paper identifies LCK-driven EGFR activation as a therapeutic target in cholangiocarcinoma, showing EGFR activity predicts response to EGFR inhibition.

This study identifies AKT as a regulator of YAP stability and shows that AKT inhibition triggers ESCRT-dependent YAP degradation, enhancing the efficacy of RAS inhibition in pancreatobiliary cancers.

This study uses SCID-rab PDX models to analyze genomic and transcriptomic features of multiple myeloma, revealing selection of pre-existing high-risk clones.

This study describes a mouse model of DHDDS-CDG, showing seizures, myoclonus, and cognitive deficits linked to glycosylation defects and interneuron abnormalities.

The paper identifies sex and experience-dependent regulation of synaptic protein turnover using SILAM in the hippocampus, finding sex-specific changes in ASD risk genes and experience-induced stabilization of PSD proteins.

This study shows that TBK1 and IKKε protect target cells from IFNγ-mediated T cell killing by suppressing inflammatory apoptosis and NFκB-driven inflammation.

This study identifies mitochondrial dysfunction and metabolic impairments in DHDDS-related juvenile parkinsonism and shows that NMN treatment improves symptoms in patient-derived organoids and clinical cases.

This study identifies IFNγ-induced HLA class I-restricted neuronal autoantigens and their recognition by CD8+ T cells using human iPSC-derived neurons and immunopeptidomics.

This study identifies biomarkers and resistance mechanisms to SFK-YAP inhibition in cholangiocarcinoma using multiomic profiling and shows synergy with chemotherapy.

The paper develops a C. elegans model of SRD5A3-CDG and identifies atorvastatin as a potential repurposed therapy through a high-throughput screen.

This study identifies unique proteomic signatures in melanoma-derived lymphatic exosomes that contribute to premetastatic niche formation in sentinel lymph nodes.

The paper identifies 70 extracellular proteins interacting with AMPARs during synaptic plasticity, showing OBCAM and NTM regulate AMPAR mobility.

This study identifies Src-mediated upregulation of EphA2 in PTEN-deficient cells and shows that combined AKT and Src inhibition synergistically suppresses tumor growth.

The paper identifies a rare multipotent epithelial cell in the fallopian tube as a potential cell-of-origin for high-grade serous ovarian cancer using multi-omic profiling and organoid models.

This study identifies cKIT as a key mediator of oxidative signaling in human mammary luminal progenitor cells and links its activation to poor outcomes in basal-like breast cancers.

This study uses cortical organoids to show that ALG13 loss-of-function causes glycosylation defects, neuronal maturation issues, and network hypoactivity in CDG.

This paper investigates the role of PGM1 in cardiomyocytes using patient-derived stem cells, finding disruptions in sarcomere and mitochondrial function, and suggesting potential therapeutic targets.

This study creates a mouse model of PMM2-CDG by selectively removing PMM2 from neural precursor cells, revealing cerebellar hypoplasia and ataxia, and showing molecular disturbances in the cerebellum that mirror human disease.

The paper establishes a salivary regenerative biobank and identifies markers and proteomic signatures of salivary gland stem and progenitor cells.

This study shows that PP2A catalytic subunit alpha is essential for CD8+ T cell homeostasis and anti-bacterial responses, with Bcl2 rescue limited to spleen.

This study shows that loss of MECR causes elevated ceramide levels and impaired iron metabolism, linking mitochondrial fatty acid synthesis to neurodegeneration.

This study shows that the TREM2-H157Y mutation increases soluble TREM2 and reduces amyloid pathology in mice, suggesting a potential protective effect against Alzheimer's disease.

The paper identifies ceramide accumulation, lysosomal expansion, and mitochondrial defects as root causes of INAD/PARK14 and tests therapeutic strategies including drugs and gene therapy.

This study uses single cell multiomic analyses to show DNMT3A mutations in clonal hematopoiesis worsen inflammatory outcomes in COVID-19 by increasing IL32 expression and chromatin accessibility.

The paper identifies complement and coagulation cascade pathways as significantly altered in two Parkinson's disease mouse models through proteome analysis.

The paper identifies proteins associated with the nuclear lamina and lamin associated domains using BioID and m6A-tracer systems, revealing key regulators of LAD function.

This study identifies potential biomarkers for intracranial aneurysm subtypes through proteomic analysis of tissue and serum samples.

This study demonstrates that EpCAM aptamer-siRNA chimeras effectively silence oncogenes in epithelial cancers, leading to tumor reduction and apoptosis.

The paper compiles RNA sequencing data from 9,795 experiments to create a new human gene catalog, identifying novel genes and transcripts while highlighting extensive transcriptional noise.

The paper establishes the landscape of human cell-specific microRNA expression using small RNA-seq data from diverse cell types and tissues, identifying novel microRNA loci and patterns correlated with super-enhancer activity.