Lin Yu

Retinal degeneration in a mouse model of CRB1 disease rescued by the photoreceptor-specific CRB1-B isoform

This study shows that restoring the CRB1-B isoform in photoreceptors rescues retinal degeneration in a mouse model of CRB1 disease by preserving adherens junctions.

Elevated EGR1 Binding at Enhancers in Excitatory Neurons Correlates with Neuronal Subtype-Specific Epigenetic Regulation

The paper identifies EGR1 binding at enhancers in excitatory neurons and shows its correlation with subtype-specific epigenetic regulation and gene pathways.

Spectral Cluster Supertree: fast and statistically robust merging of rooted phylogenetic trees

The paper introduces a new supertree method, Spectral Cluster Supertree, which efficiently merges rooted phylogenetic trees with improved accuracy and speed compared to existing methods.

Genome-wide mapping of native co-localized G4s and R-loops in living cells

The paper develops methods to map native co-localized G4s and R-loops in living cells and shows their role in transcriptional regulation.

Single-cell RNA sequencing of iPSC-derived brain organoids reveals Treponema pallidum infection inhibiting neurodevelopment

This study uses single-cell RNA sequencing to show that Treponema pallidum infection impairs neurodevelopment in iPSC-derived brain organoids by reducing subNPC1B cells and hindbrain neurons.