TRAF6 directs Foxp3 localization and facilitates Treg function through K63-type ubiquitination
Xuhao Ni, Jinhui Tao, Jian Gu, Benjamin V. Park, Zuojia Chen, Stephanie Newman, Hongbin Shen, Xuehao Wang, Bin Li, Bruce R. Blazar, Joseph Barbi, Fan Pan, Ling Lu
This study shows TRAF6 ubiquitinates Foxp3 at K262, ensuring its proper localization and function in Tregs, which enhances anti-tumor immunity.
bioRxiv · May 7, 2018 · PreprintImmunology