Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin's hunger-suppressing effects
Frankie D. Heyward, Nan Liu, Christopher L. Jacobs, Rachael Ivison, Natalia Machado, Aykut Göktürk Üner, Harini Srinivasan, Suraj J. Patel, Anton Gulko, Tyler J. Sermersheim, Stuart H. Orkin, Linus Tsai, Evan D. Rosen
The paper identifies IRF3 as a key transcriptional regulator of leptin's hunger-suppressing effects in AgRP neurons through integrated genomic analysis.
Nature Communications · May 31, 2024Peer-reviewedNeuroscience