Christopher L. Jacobs

This study uses snRNA-seq to analyze human adipose tissue depots, identifying distinct adipocyte and progenitor subpopulations and depot-specific intercellular communication networks, with changes observed in disease states.

This study identifies rapid remodeling of human subcutaneous white adipose tissue within one month after bariatric surgery using snRNA-seq, revealing changes in adipocyte populations and transcriptional dynamics.

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

The paper uses single-nuclear RNA sequencing to analyze adipose tissue in lymphedema patients, identifying a stromal cell population that promotes lymphangiogenesis.

The paper identifies IRF3 as a key transcriptional regulator of leptin's hunger-suppressing effects in AgRP neurons through integrated genomic analysis.

This study creates a spatially-resolved transcriptional atlas of the murine dorsal pons using snRNA-seq and MERFISH, identifying 120 neuronal subtypes and their spatial distribution.

This study identifies the IRF3/AIG1 axis in adipocytes as a mechanism linking obesity-induced inflammation to insulin resistance and suggests AIG1 inhibition as a therapeutic approach.

This study shows aging impairs beige adipogenesis and adipocyte metabolic responses to cold, identifies Npr3 as a marker gene, and provides insights into age-related adipose tissue dysfunction.

This study shows that mesothelial cells are not a source of visceral adipocytes in mice, challenging a recent paradigm based on Wt1 lineage tracing.