Author

Lior Lasman

Weizmann Institute of Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Jacob H. HannaiD· 5 shared Sergey V. Viukov· 4 shared Alejandro Aguilera-CastrejoniD· 3 shared Mirie ZerbibiD· 3 shared Noa NovershterniD· 3 shared Nofar MoriD· 3 shared Shay GeulaiD· 3 shared Vladislav Krupalnik· 3 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersDevelopmental Biology

Jacob H. HannaORCID

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Author profile →

5 papers

Recent·Most cited

Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

David Dierks, Ran Shachar, Ronit Nir, Miguel Angel García-Campos, Anna Uzonyi, David Wiener, Ursula Toth, Walter Rossmanith, Lior Lasman, Boris Slobodin, Jacob H. Hanna, Yaron E. Antebi, Ruth Scherz‐Shouval, Schraga Schwartz

The paper introduces a differential model m6ADyn to predict m6A dynamics by integrating mRNA metabolism and validates its predictions through experimental confirmation.

eLife · Jun 30, 2025Peer-reviewedSystems Biology

Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naive Pluripotency

Jonathan Bayerl, Muneef Ayyash, Tom Shani, Yair S. Manor, Ohad Gafni, Rada Massarwa, Yael Kalma, Alejandro Aguilera-Castrejon, Mirie Zerbib, Hadar Amir, Daoud Sheban, Shay Geula, Nofar Mor, Leehee Weinberger, Segev Naveh‐Tassa, , Jacob H. Hanna

This study identifies signaling pathways that enable the expansion of human naive pluripotent stem cells in defined conditions and highlights differences between mouse and human naive pluripotency.

Cell stem cell · Apr 28, 2021Peer-reviewedDevelopmental Biology

Context-dependent functional compensation between Ythdf m6A readers

Lior Lasman, Vladislav Krupalnik, Shay Geula, Mirie Zerbib, Sergey V. Viukov, Nofar Mor, Alejandro Aguilera-Castrejon, Orel Mizrahi, Shashank Sathe, Aharon Nachshon, Dan Schneir, Stefan Aigner, Archana Shankar, Jasmine R. Mueller, Noam Stern‐Ginossar, , Jacob H. Hanna

The paper investigates functional compensation among Ythdf m6A readers in mouse gametogenesis and embryonic stem cells, revealing dosage-dependent redundancy and distinct roles.

bioRxiv · Jun 3, 2020 · PreprintDevelopmental Biology

Deciphering the ‘m6A code’ via quantitative profiling of m6A at single-nucleotide resolution

Miguel Angel García-Campos, Sarit Edelheit, Ursula Toth, Modi Safra, Ran Shachar, Sergey V. Viukov, Roni Winkler, Ronit Nir, Lior Lasman, Alexander S. Brandis, Jacob H. Hanna, Walter Rossmanith, Schraga Schwartz

This paper introduces MASTER-seq, a method to quantitatively profile m6A sites at single-nucleotide resolution, revealing a predictable code that determines m6A stoichiometry and dynamics.

Cell · Jun 27, 2019Peer-reviewedMolecular Biology

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Nofar Mor, Yoach Rais, Daoud Sheban, Shani Peles, Alejandro Aguilera-Castrejon, Asaf Zviran, Dalia Elinger, Sergey V. Viukov, Shay Geula, Vladislav Krupalnik, Mirie Zerbib, Elad Chomsky, Lior Lasman, Tom Shani, Jonathan Bayerl, , Jacob H. Hanna

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.

Cell stem cell · Aug 16, 2018Peer-reviewedDevelopmental Biology