BNCT Triggers Immunogenic Cell Death in B16 Melanoma Without Accompanying T-Cell Infiltration--Implications for Combination Immunotherapy
Rui Quan, Hefa Huang, Lili Zhang, Chengyu Zhang, Shuyu Chang, Menglin Wu, Shixu Zhang, Lu Zhang, Zhongying Dai, Long Gu
This study shows BNCT reduces B16 melanoma growth and survival, induces immunogenic cell death and a Th1 response, but fails to increase CD8+ T-cell infiltration, suggesting immune resistance mechanisms may limit its efficacy.
bioRxiv · Nov 5, 2026 · PreprintCancer Biology