Lu Zhang

BNCT Triggers Immunogenic Cell Death in B16 Melanoma Without Accompanying T-Cell Infiltration--Implications for Combination Immunotherapy

This study shows BNCT reduces B16 melanoma growth and survival, induces immunogenic cell death and a Th1 response, but fails to increase CD8+ T-cell infiltration, suggesting immune resistance mechanisms may limit its efficacy.

Maleic acid adjuvates BCG to induce CD4+CD8+ T cells and sterilize tuberculosis

This study shows that maleic acid enhances BCG vaccination to induce CD4+CD8+ T cells that sterilize Mtb infection in mice.

Chronic kidney disease promotes anxiety susceptibility through an angiotensin II central amygdala axis

This study identifies a mechanism by which chronic kidney disease promotes anxiety through a central amygdala angiotensin II signaling pathway.

Peri-Locus Coeruleus Controls Endothelial Cell Heterogeneity in Enriched Environments via Region-Specific Norepinephrine Signaling

This study shows that peri-LC neurons regulate bone endothelial heterogeneity and density through norepinephrine signaling in enriched environments.

Incomplete lineage sorting of segmental duplications defines the human chromosome 2 fusion site early during African great ape speciation

The paper identifies three ancient segmental duplications at the human chromosome 2 fusion site, showing their differential distribution due to incomplete lineage sorting and their regulatory impact on gene expression.

GPR17 structure and agonism with small molecules and oxysterols

This study presents cryo-EM structures of GPR17 with ligands and shows orthosteric and allosteric binding mechanisms, suggesting alternative approaches for drug discovery.

Palbociclib CDK4/6- and Crizotinib MET/ALK/ROS1-inhibitors Synergize to Enhance Senescence and Immune Recognition in Melanoma Cells Independently of BRAF/NRAS Status

This study shows that combining palbociclib and crizotinib enhances senescence and immune recognition in melanoma cells regardless of BRAF/NRAS status, reducing tumor growth.

Altered susceptibility of rare yeast species causing vulvovaginal candidiasis at acidic vaginal environment

This study assesses antifungal susceptibility of rare yeast species causing VVC at acidic pH, finding that terconazole, amphotericin B, and nystatin show increased MICs at pH 4.5 compared to pH 7.0, while 5-flucytosine remains unaffected.

Comparative genomics of macaques and integrated insights into genetic variation and population history

This study presents genome assemblies and analyses of macaques to explore genetic variation, population history, and evolutionary differences between species and humans.

High-throughput Monoclonal Antibody Screening from Immunized Rabbits via Droplet Microfluidics

This study develops a droplet microfluidics-based method to efficiently discover high-affinity rabbit monoclonal antibodies by overcoming B cell enrichment challenges.

Recombinant Protein IGF1-24 Stimulates Rat Cardiomyocytes Proliferation and Repairs Myocardial Injury

This study shows that recombinant IGF1-24 promotes cardiomyocyte proliferation and repairs myocardial injury in rats.