Protein degradation shapes developmental tempo in mouse and human neural progenitors
Shota Nakanoh, Despina Stamataki, Lorena Garcia-Perez, Chiara Azzi, Hayley L. Carr, Alexandra V. Pokhilko, Loukik Doshi, Giulia L. M. Boezio, Manuela Melchionda, Lu Yu, Steven A. Howell, Mark J. Skehel, David Oxley, Simon Andrews, James Briscoe, Teresa Rayón
The paper compares protein dynamics in mouse and human neural progenitors, finding that human NPs have longer protein half-lives and lower proteasomal activity, which influences developmental tempo.
bioRxiv · Aug 1, 2024 · PreprintDevelopmental Biology