Proximity biotinylation at the host-Shigella interface reveals UFMylation as an antibacterial pathway.
Ana T. López-Jiménez, Fabien Théry, Kathryn Wright, Hannah Painter, Shelby T. Hoffmeister, Lucas Jarche, Jeremy J. R. Benjamin, Gerbrand J. van der Heden van Noort, Dominik Brokatzky, Margarida Castro Gomes, Sydney L. Miles, Damián Lobato‐Márquez, Eva‐Maria Frickel, John R. Rohde, Jonathan N. Pruneda, , Serge Mostowy
The paper identifies UFMylation as an antibacterial pathway using proximity biotinylation and mass spectrometry, showing it targets intracellular Shigella and Salmonella.
Nature Communications · Sep 17, 2026Peer-reviewedMicrobiology