Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas
Laabiah Wasim, Sin Wah Tooki Chu, Benjamin Sale, Lucy Pickard, Simon Léonard, Lingling Zhang, Helena Tolarová, Zhang Sung Tean, Niklas Engels, Dinis Pedro Calado, Karin Tarte, Jessica Okosun, Francesco Forconi, Pavel Tolar
This study identifies mutations in the IgG heavy chain in follicular lymphoma and EZB DLBCL that enhance BCR signalling and oncogenicity by disrupting the IgG intracellular tail.
bioRxiv · Apr 12, 2024 · PreprintImmunology