Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis
Victoire Boulat, Elena Alberts, Paul C. Driscoll, Miu Shing Hung, Ana Cunha, Jelmar Quist, Fangfang Liu, Carin Andrea Brundin, Ananya Bhalla, Lidia Avalle, James Rosekilly, Lucy Ryan, Cheryl Gillett, Molly Strom, Valeria Poli, , Dinis Pedro Calado
This study identifies lactate as a tumor-secreted metabolite that inhibits B cell chemotaxis and TLS formation in TNBC by disrupting mitochondrial metabolism.
bioRxiv · Aug 30, 2025 · PreprintCancer Biology