Stefania Marcotti

This study identifies a GlcChol-RAC1-actin signaling axis linking GBA2 loss-of-function to synaptic and mitochondrial dysfunction in SPG46, with Rac1 inhibition rescuing disease phenotypes in a zebrafish model.

This paper improves cryo-volume Electron Microscopy (cvEM) techniques for imaging whole cells and tissues, demonstrating enhanced resolution using Caenorhabditis elegans and Paramecium bursaria.

The paper uses FLIM to measure chromatin compaction in TNBC tissues and finds that spatial chromatin states predict resistance to neoadjuvant chemotherapy.

This study examines how Tau35 protein affects lysosomal function and autophagy, identifying early pathological changes linked to neurotoxicity in tauopathies.

This study shows that blocking mechanical damage in airway epithelia during asthma reverses airway remodelling and hyperresponsiveness, suggesting asthma may be curable.

The paper introduces SMART, a spatio-molecular atlas of TNBC response trajectories, revealing distinct epithelial archetypes and tumor-immune microenvironments associated with treatment response and prognosis.

This study reanalyzes image datasets to emphasize robust experimental design and effect sizes over statistical significance, providing open-access code to improve reproducibility.

This study develops and simulates a computational model to understand how cell properties affect collective alignment, finding optimal self-propulsion and overlap avoidance ratios, and the role of deformability and junctions.

GliaMorph quantifies Müller glial cell morphology across developmental and disease states, revealing structural changes and subcellular features in zebrafish and mouse models.

This study shows that extracellular matrix assembly stress actively drives morphogenesis in Drosophila ventral nerve cord by generating surface tension during collagen-IV network formation.